Thursday, May 03, 2007

Smart-gene regulation...

The last specimen done and ridden with. Why is it so hard to understand all these damn hard questions? All tricky and criss-cross? I tell you why, it's because we are different from the prof's level. Level of what? Age? Knowledge? No... It is regulation, regulation in expression of genes in fact.

We have a whole different level of regulation as compared to the profs. Why is that so? It comprise of many factors, the more prominent ones are due to epigenetic changes or presence of repressors that inhibit expression of our smart-gene. Studies have shown that there is a dominant repressor called the smart-o-pressor that binds strongly to the smart-gene promoter. There is still tests going on to test out whether there are other transcriptional factors that prevent the transcription of the smart-gene. Dr Jo, a Phd achiever at the age of 23 expresses his experience, "It is hard to come to a conclusion on what actually affects the expression levels. The fact that expression of mRNA is still so ambiguous that it's not easy to pin-point the exact location of the specific transcriptional factor binding on the DNA or whether it is of the structural formation of the mRNA that enhances the translational levels of the smart protein. It can even be a steroid receptor that causes it's enhancement. I have run tests as long as 5 years and my team and I are still on the brinks of getting more results from the tests. We are confident that there IS a difference in regulational levels that causes the difference between profs and students. In fact, there is a hypothesis that the levels of stresscolin may be an influence to the expression levels of the smart gene. However, there is little evidence on that subject..."

The human body is a mysterious thing, even with the layout of the human genome itself. Like what Dr Jo has mentioned, it's hard to conclude the probably cause of this change. To have fun or to study? To increase our stresscolin or fun-o-kinase? Though both pathways have their advantage, they, too, have their flaws. With such ambiguity, thus, there is a emphasis on the need to research on this area of interest, who knows, maybe there can be a possibility of knocking in more smart-genes for higher expression rates.

Adapted from one of Dr Jo's journals
The Mix Boy

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